Aryastha offers cutting-edge services and alliances, leveraging our advanced technology platform and comprehensive capabilities across the drug discovery process. With a distinguished track record, experienced scientists, and an innovative approach, we set ourselves apart in the industry.
Pre-Clinical DMPK
Aryastha provides a comprehensive range of services encompassing in vitro ADME, toxicity (in vitro ADMET), and in vivo pharmacokinetics (PK), offering rapid evaluations of test articles DMPK properties and toxicity. Our team specializes in crafting robust DMPK packages tailored for submissions to regulatory agencies like FDA, MHRA and GLP.
Integrated drug discovery services encompass a range of offerings designed to bolster and expedite drug development while cutting down the time and expenses required for introducing new drugs. The drug discovery process is intricate and demanding, spanning various phases such as target identification, lead discovery, optimization, preclinical, and clinical development. These comprehensive services excel in identifying potential challenges at an early stage of drug development, thereby contributing to cost savings by mitigating the expenses linked to unsuccessful drug development initiatives.
Process Chemistry Services
Our dedicated process chemistry team is committed to aiding you in route scouting and crafting a process tailored to your project's needs. This process guarantees safety, reproducibility, robustness, and superior quality. All our process development endeavors are guided by Quality by Design (QbD) principles, integrating analytical and risk-management methodologies throughout molecule design, development, and manufacturing stages.
Route Exploration and Process Development
The process begins with designing the route, which involves conducting retrosynthetic analysis, practical evaluation for yield enhancement, and ensuring safety through thorough thermodynamic studies. This leads to route investigation, encompassing in-depth exploration of potential routes and method development. The process is developed, optimizing both early and late-stage processes, employing strategically designed experiments (DoE), and troubleshooting reactions.
Tailored Scale-Up Solutions
Navigating the transition from preclinical to commercial-scale manufacturing brings intricate challenges and intricacies. Our custom scale-up service encompasses in-house production ranging from hundreds of grams to kilograms of non-GMP material, serving demo batches, proof of principle, and preclinical studies. Seamlessly transferring technology to larger scales and ensuring GMP-compliant manufacturing is a pivotal aspect of our offering.
Analytical Solutions
Leveraging a wealth of experience, our analytical specialists expedite the transformation of your molecule from conception to clinical stages and beyond with unwavering success. Complemented by abundant capacity and diverse analytical insight, we provide our clients unparalleled access to a team of genuine problem solvers well-versed in the entire product life cycle. With an arsenal of cutting-edge analytical and synthetic equipment, we excel in conducting meticulous impurity identification for drug substances.
Route Scouting
Pioneering Efficiency Route scouting is foundational in identifying a safe, efficient, and cost-effective synthesis process for large-scale production. Key questions encompass safety considerations, raw material availability and affordability, patent implications, intermediate stability, purification methods, environmental concerns, and alternative routes derived from thorough literature reviews. Regulatory compliance is also weighed, shaping decisions that optimize time, cost, and quality. Our approach integrates these crucial aspects to formulate an optimized route.
Analytical Suppport
Our integrated analytical support entails method development and synthesizing and purifying analytical standards to empower accurate analysis and quality assessment.
Oncology
Our oncology services offer advanced techniques including cancer cell panel screening, cell proliferation studies (CellTiter Glo), 3D culture assays, apoptosis analysis, and target validation (shRNA, RNAi, Crispr-Cas9). Additionally, we provide characterization of cell/animal models through whole exome and RNAseq analyses. Our comprehensive approach enables significant progress in cancer research.
Metabolic Disorder
In the realm of metabolic disorder research, our services encompass GSIS (Intact islet/pancreatic beta cell) assessments, fatty acid synthesis and oxidation assays, TCA cycle evaluations, glucose uptake studies, and the detection of TG, glycogen, and ketone bodies. Our comprehensive capabilities facilitate insightful discoveries in the field of metabolic disorders.
Immunology
Our immunology services encompass diverse techniques, including cytokine/chemokine profiling, T cell activation/proliferation, B cell and NK cell activation, ADCC, and immune cell co-culture with tumor cells. We specialize in PD1/PD-L1 binding assays, immune checkpoint evaluations, and immune reporter cells. Our offerings extend to engineered cel
